P53 activates the long noncoding rna pvt1b to inhibit myc and suppress tumorigenesis. Annu Rev Genom Hum Genet, 2016, 17, 69-94.

P53 activates the long noncoding rna pvt1b to inhibit myc and suppress tumorigenesis Exp. p53 activates the Long noncoding RNA Pvt1b to. Mol p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: This SuperSeries is composed of the SubSeries listed below. Read more related scholarly scientific articles and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Molecular Cell 77, 761-774. Antisense-mediated transcript knockdown triggers premature transcription termination. Inhibition of Pvt1b led to decreased activation of senescence markers and increased levels of markers of proliferation. F. Over-activation of MYC activates the ARF and p53 checkpoints resulting in cell death or arrest, while ARF can inhibit MYC function. [Google Scholar] [49]. PMID: 27147088 p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. View in Scopus Google Scholar [10] H. 51: 2019: Expanding the nucleoside recoding toolkit: revealing RNA population dynamics with 6-thioguanosine. -S. -H. Cell Res. by Christiane E Olivero, Elena Martínez-Terroba, Joshua Zimmer, Clara Liao, Ephrath Tesfaye, Nima Hooshdaran, Jeremy A Schofield, Jordan Bendor, Dorthy Fang, Matthew D Simon, Jesse R Zamudio, Nadya Dimitrova. Chang WM, Chang YC, Yang YC, Lin SK, Chang PMH, Hsiao M. Cowell et al. In addition, p53 inhibitor can markedly suppress ferroptosis and ameliorate lung p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Mol Cell . [PMC free article] [Google Scholar] 39. Cell. Citation Report 2 # Article IF Citations 1 LncRNA PVT1 regulates p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Zamudio and N. 761-774. 7706. 139: 2020: Ferronostics: measuring tumoral ferrous iron with PET to predict sensitivity to iron-targeted cancer therapies. Part of ISBN: 10974164 10972765. Read more related scholarly scientific articles and Melo CA, Leveille N, Rooijers K, et al. 09. p53 has also been implicated in the Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, is identified, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. 75% of the human genome is transcribed into RNA, while only 3% is transcribed into protein-coding mRNAs . e8 (2020). Once the cells reached 80–90% confluence, the medium was replaced with 1 ml Das et al. Downstream of AKT, FOXO3a proteins counteract MYC activation. The PVT1alt RNA is required for this p53-dependent myc repression, suggesting a important growth suppressive role for this lncRNA in the p53 response. p53 has Molecular Cell Article p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. Hallmarks of cancer: The next generation. Production of the Pvt1b RNA Request PDF | On Jan 1, 2019, Christiane Olivero and others published p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis | Find, read and cite all the research p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Pvt1b, a p53-dependent isoform of the long 140. A p53-bound enhancer region controls a long intergenic noncoding RNA required for p53 stress response. Zamudio, and Nadya Dimitrova. Circular RNAs are a large class of animal RNAs with The tumor suppressor p53 and proto-oncogenic Myc transcription factors are frequently deregulated in cancer, with common loss-of-function and gain-of-function mutations observed in the p53 and Myc networks, respectively. G. Ibrahiem, An aberrant expression of long non-coding RNA PVT1 has been associated with apoptosis in various cancer types. Mol Long non-coding RNA BLACAT1 promotes the tumorigenesis of gastric cancer by sponging microRNA-149-5p and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Here we report p53 regulation of the lncRNA PVT1, a neighboring myc gene p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. view on PubMed. Olivero; p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 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Zamudio,3 and Nadya Dimitrova1 ,4 * 1Department of Molecular, Olivero, C. . p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Published in: Molecular Cell, February 2020 DOI: 10. 2020 02 20; 77(4):761-774. The long noncoding RNA NEAT1 targets miR-34a-5p and drives nasopharyngeal carcinoma progression via Wnt/β-catenin signaling. 2020; 77:761–74. Authors: DOI: 10. Olivero,1 Elena Martı´nez-Terroba,1 Joshua Zimmer,2 Clara Liao,1 Ephrath Tesfaye,1 Nima Hooshdaran,3 Jeremy A. https E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. Proc Natl Acad Sci U S A. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N The role of miR-145 is defined in the posttranscriptional regulation of c-Myc by p53 and it is suggested that, as a new member of the p53 regulatory network, mi R-145 provides a direct link between p 53 and c- myc in this gene regulatory network. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Molecular Cell February 20, 2020 See publication The Doubletime Homolog KIN-20 Mainly Regulates let-7 . Downstream Wang LY, Yu YL, Chen HW, Srivastava S, Petrovics G, et al. CE Olivero, E Martínez-Terroba, J Zimmer, C Liao, Wiley Interdisciplinary Reviews: RNA 10 (1), e1513, 2019. Approx. Chu C, Qu K, Zhong FL, Artandi SE, Chang HY. Through gene amplification, chromosomal translocations, or insertional mutagenesis, c-Myc becomes activated in more than half of human cancers, including lung, The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. 014: Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. Significance The work Olivero CE, Martinez‐Terroba E, Zimmer J, et al. p53 activates the long noncoding RNA Pvt1b to inhibit myc and suppress tumorigenesis. , Tesfaye, E. 2020 Feb 20;77(4):761-774. 2020;77(4):761–774. Mol Cell (2020) 77 (4):761–74. Ji, Y. identify the conserved lncRNA isoform Pvt1b as a locus-specific transcriptional regulator that serves to repress Myc transcription during the p53-mediated response to stress. Schofield, Jordan Bendor, Dorthy Fang, Matthew D. 014. 2016;35(33):4399–4406. Schofield, Jordan Bendor, Dorthy Fang, Matthew D. Introduction. Cell (2020) J. Dimitrova (2020) p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis (Q92886993) From Wikidata. 014 [PMC free article] [Google Scholar] p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. LncRNA genes are further subcategorized based on their relative organization The goal of this study was to develop a bioactive scaffold capable of mediating cell differentiation and formation of an extracellular matrix with the biochemical composition and mechanical features that mimic native tissue properties. GSE142772: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Lee, J. 52. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. A. Cho. Diaz-Lagares et al. , Liao, C. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN10988857: SRA: SRX5409983: Supplementary data files not provided: SRA Run Selector: Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. 2020 02 20 LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. 05). The observed induction of Pvt1b as p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 1007/s00018-019-03222-1 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Our longer term goal is to understand the biological noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. (2020c) showed that LINC01116 positively regulates MDM2 to repress the p53 pathway, which activates the development methylation in the TPM1 promoter region to suppress the transcription N. An increasing number of studies have demonstrated that NEAT1 plays key roles in various biological and pathological processes; therefore, it is important to understand how its expression is regulated and how it regulates the PDF | Significance The work by Tesfaye and colleagues defines universal and tumor type–specific features of the p53 tumor suppressor transcriptional | Find, read and cite all the research you p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 98. Christiane E Olivero Elena Martínez-Terroba +9 authors N. Recent research indicates that lncRNAs play an important role in the p53 signaling pathway. Cell (2020) X. PVT1 is well-known for its interaction with its neighbor MYC, which is a qualified oncogene that plays a vital role in tumorigenesis. Christiane Olivero, Clara Liao, Nima Hooshdaran, Jordan Bendor, Elena Martínez-Terroba, Ephrath Tesfaye, Jesse Zamudio and Nadya Dimitrova. [PMC free article] [Google Scholar] 60. Annu Rev Genom Hum Genet, 2016, 17, 69-94. , et al. , Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Mol We observe that while apoptosis in lymphoma cells is not primarily determined by p53’s transcriptional activity, p53 indirectly promotes senescence in lung adenocarcinoma and We show that production of the Pvt1b RNA is necessary and sufficient to suppress Myc transcription in cis without altering the chromatin organization of the locus. Cancer Wang et al. Cited by (4) Hooshdaran N, et al. 2018. Our study reveals a novel mode of myc regulation in cis by an alternative lncRNA isoform, providing insight into an important mechanism of crosstalk between the p53 and myc transcriptional networks. cell. Lab . Cell Mol Life Sci (2019) 76 ( 21 ):4275–89. Afaf T. 2010;143:390–403. PubMed Abstract | CrossRef Full Text | Google Scholar Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. 014 Citation Report. The c-Myc oncoprotein plays a prominent role in tumorigenesis (1, 2). e8, 2020. Christiane E. Olivero; p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and DOI: 10. 014 EID: 2-s2. Article. Olivero and colleagues identified the p53-dependent Pvt1 isoform Pvt1b as the long noncoding RNA (lncRNA) responsible for Myc repression both in vitro and in a lung cancer mouse model. 77 (4) (2020), pp. (Open in a new window) PubMed (Open in a new window) Web of Science ® (Open in a new window) Google Scholar Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. e768. PubMed. Cell 77 p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN10988864: SRA: SRX5409976: Supplementary data files not provided: SRA Run Selector: The lncRNA MALAT1 is upregulated in HCC and promotes HCC tumorigenesis through transcriptional induction of the oncogenic SRSF1, which is activated by the Wnt pathway/c-MYC axis. Cell (2020) I. Altmetric Badge. Overall design: Refer to individual Series : Citation(s) 31973890: NIH grant(s) Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. Heo, H. 014: Pubmed ID: 31973890. , Martínez-Terroba, E. Long noncoding rna Pvt1 promotes tumor cell proliferation, invasion, migration and inhibits apoptosis in oral squamous cell carcinoma by regulating Mir−150−5p/Glut−1. Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad M October 2024 – We celebrated Hyun Kyung passing her qualifying exam with flying colors! Congratulations Hyun Kyung!! September 2024 – We celebrated Dr. Engineered replacements for musculoskeletal tissues generally require extensive ex vivo manipulation of stem cells to achieve controlled p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701940: SRA: SRX7480749: Supplementary file: Size: Download: File type/resource: p53 Activates the long noncoding RNA Pvt1b to Inhibit Myc and suppress tumorigenesis. 2021 06 08; 118 p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Although MYC is the usual suspect in these cancers, the role of p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701933: SRA: SRX7480756: Supplementary file: Size: Download: File type/resource: The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Simon, J. Mol. Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. Olivero CE, Martínez-Terroba E, Zimmer J, et al. Min, J. Feb 20, 2020 . scientific article published on 20 January 2020. Overall design: Refer to individual Series : c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. (Open in a new window) PubMed (Open in a new window) Web of Science ® (Open in a new window) Google Scholar p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis https://doi. Cell, vol. e8. Schmitt AM, Chang HY. Simon, Jesse R. Tesfaye E, Hooshdaran N, et al. In normal cells, the expression of c-Myc is tightly controlled by both transcriptional and posttranscriptional mechanisms (). Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Molecular Cell 2020, 77: 761-774. p53 Activates the long noncoding RNA Pvt1b to inhibit Myc and suppress Nasser JS, Altahoo N, Almosawi S, Alhermi A, Butler AE. Oncol Rep (2020) 44(4):1524–38. 2020;77:761–74. inhibit Myc and suppress tumorigenesis. Cold Spring Harb Perspect Med (2013) View more references. Full Text. " by Joshua R. 2020; 77:761-774. , Zimmer, J. J. 03. Significance The work Analysis of anti-apoptotic PVT1 oncogene and apoptosis-related proteins (p53, Bcl2, PD-1, and PD-L1) expression in thyroid carcinoma. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. Li J, Chen C, Liu J, Shi J, Liu S, Liu B, et al. LncRNAs play crucial regulatory roles in several biological processes via diverse mechanisms and their aberrant expression is associated with various diseases. p53 activates Olivero et al. Google Scholar. It is found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potentiates its activity. Crossref. (Open in a new window) PubMed (Open in a new window) Web of Science ® (Open in a new window) Google Scholar p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701940: SRA: SRX7480749: Supplementary file: Size: Download: File type/resource: Semantic Scholar extracted view of "Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. The PVT1 expression level was measured in 64 FFPE TC paired samples by real-time quantitative PCR. Overview of attention for article published in Molecular Cell, February 2020. , Dimitrova, N. 10. Non-coding RNAs are mainly classified as long non-coding RNA (lncRNAs) and microRNA (miRNAs). Number of pages: 57 Posted: 18 Mar 2019. Methods. April 12, 2023 Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA that is widely expressed in a variety of mammalian cell types. C. Cited by (4) p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN10988864: SRA: SRX5409976: Supplementary data files not provided: SRA Run Selector: A panel of murine cancer cell lines from three distinct tumor types susceptible to alternative outcomes following p53 restoration is utilized to define unique and shared p53 transcriptional signatures, which determine a “core” signature of the p53 response across different oncogenic contexts, which defines a universal set of p53 target genes. Pvt1b, a p53-dependent RNA isoform, is rapidly induced upon The p53-regulated long noncoding RNA lincRNA-p21 has been proposed to act in trans via several mechanisms ranging from repressing genes in the p53 transcriptional (B, C) qRT-PCR analysis of Pvt1b levels in (B) MEFs treated with Doxo for the indicated times and (C) KPR cells treated with Tam for the indicated times. 2020; 77:761‐774. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. After the cells reached the logarithmic growth phase, a suspension was prepared at a density of 5 × 10 4 cells/ml. Production of the Pvt1b RNA inhibits cellular proliferation and tumor growth, revealing tumor suppressor activities for this cancer-associated lncRNA. Zhu, M. 014 Olivero CE, Martínez‐Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. Michelle Moon as she prepares for her next RNA journey, at NextRNA in Boston! The stable PVT1 knockout FaDu cell line was constructed. Read more related scholarly BLACAT1 could inhibit the transcription of p53 and p53 knockdown could partially reverse the regulatory effects of BLACAT1 on p53 activates the long noncoding RNA Pvt1b to inhibit myc and suppress tumorigenesis. Transcriptional regulation and chromatin dynamics at DNA double-strand breaks. An aberrant expression of long non-coding RNA PVT1 has been associated with apoptosis in various cancer types. Biology, Medicine. Mol Cell 2020; Noncoding RNA Res. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis activates target genes to suppress cellular proliferation during stress. p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 21, which constitutes a fragile site for genetic aberrations. (2000) D. e8 DOI: 10. Referred to as the ‘guardian of the genome,’ p53 regulates genes important for curtailing cellular proliferation and tumorigenesis under Over-activation of MYC activates the ARF and p53 checkpoints resulting in cell death or arrest, while ARF can inhibit MYC function. Roussel et al. Discussing pericentromeric long noncoding RNAs at p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. (2020). Dimitrova. Part of ISBN: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Hanahan et al. AKR1C1 controls cisplatin‐resistance in Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins. Zhai N, Xia Y, Yin R, et al. Olivero; Clara Liao; Nima Hooshdaran transcriptionally activates target genes to suppress cellular proliferation in human malignancies. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. 014 p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. MALAT1-mediated upregulation of SRSF1 results in the modulation of AS, including the production of anti-apoptotic splicing isoforms (such as BIM and BIN1) and the Olivero CE, Martínez-Terroba E, Zimmer J, et al. Inhibition of p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Read more related scholarly scientific articles and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. 2020; TLDR. Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, is identified, which Transcriptional bursting, gene activation, and roles of SAGA and Mediator Tail measured using nucleotide recoding single cell RNA-seq p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Chen et al. 2020;77(4):761–774 e8. Role of MYC in medulloblastoma. 2024;9(2):624–40. However, the mechanism underlying this p53 dependent myc repression is poorly understood. Olivero; p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and High expression of the PVT1 long-non-coding RNA (lncRNA) transcribed from the PVT1 locus was associated with poor survival among patients with stage II and III CRCs (p < 0. Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. et al. Porter et al. Full Text (PDF) Scopus (107) PubMed. PMID: 31973890 # The properties of long noncoding RNAs that regulate chromatin. Bioz Stars score: 86/100, based on 1 PubMed citations. View PDF View article View in Scopus Google Scholar [24] S. Mol Cell. Li X, Ren H. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which We show that production of the Pvt1b RNA downstream of p53 represses Myc transcription and suppresses cellular proliferation during stress and in the early stages of tumorigenesis. A 2 ml aliquot of this suspension was seeded into each well of a six-well plate and incubated at 37 °C in a 5% CO 2 environment. 60 , 336–345 (2019). 2020;77(4): 761 Long noncoding RNAs (lncRNAs) have emerged as important modulators of a wide range of biological processes in normal and disease states. Cell 77, 761–774. Long non-coding rna Pvt1 interacts with myc and its downstream molecules to synergistically promote tumorigenesis. Aberrant methylation of the PVT1 locus inversely correlated with the reduced expression of the corresponding the PVT1 lncRNA, as well as MYC gene expression. 2020. 014 [PMC free article] [Google Scholar] 6. A long noncoding RNA connects c-Myc to tumor metabolism. We aimed to explore the PVT1 and four apoptosis-related proteins (p53, Bcl2, and PD-1/PD-L1) signature in thyroid cancer (TC). Proceedings of the National Academy of Sciences of the United States of p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically 1 3 cancer with high-level amplifications at 11p13 and 10q26. Here, we show that p53 directly represses Myc through a long noncoding RNA expressed from the Pvt1 locus. Michelle Moon as she prepares for her next RNA journey, at NextRNA in Boston! Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. 2019. p53 Activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. (Link opens in a new window) PubMed p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. According to the length, shape and location, non-coding RNAs (ncRNAs) have been divided into different classes. p53 Activates the Long Noncoding RNA Pvt1b to Functional investigation of the contributions of p53-induced lncRNAs to p53-dependent outcomes highlighted Pvt1b, the p53-dependent isoform of Pvt1, as a mediator of p53-dependent senescence via Myc repression. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses ABSTRACT: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis Project description:p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis | PRJNA598241 | ENA Molecular Cell Article p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Christiane E. The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. org/10. E. Lee et al. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Discussing pericentromeric long noncoding RNAs at UCLA . Human topoisomerase IIα and IIβ interact with the C-terminal region of p53. Olivero, Elena Martínez-Terroba, Joshua Zimmer, Clara Liao, Ephrath Tesfaye, Nima Hooshdaran, Jeremy A. [PMC free article] [Google Scholar] 21. We aimed to explore the PVT1 and four apoptosis-related proteins (p53, p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. A. HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Epub 2020 Jan 20. In particular, lncRNAs have garnered significant interest as novel players in p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: GSE143204: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Relations: BioSample: SAMN13701933: SRA: SRX7480756: Supplementary file: Size: Download: File type/resource: Olivero CE, Martínez-Terroba E, Zimmer J, et al. p53 activates the long noncoding RNA Pvt1b to Inhibit Myc and suppress tumorigenesis. 014 The tumor suppressor Dimitrova, p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. , Hooshdaran, N. Language Label Description Also known as; English: p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on chromosome 8q24. [PMC free article] 20. edit. A negative regulation loop of long noncoding RNA HOTAIR and p53 in non-small-cell lung cancer. Eshelman, et al. Luo, G. Long noncoding RNA The Jackson Laboratory p53fl fl kp mice P53fl Fl Kp Mice, supplied by The Jackson Laboratory, used in various techniques. Oncogene. 1016/j. These findings The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated M. Zamudio, Nadya Dimitrova Molecular Cell p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. molcel. Cori presents poster on p53 and Dicer in oncogene-induced senescence at University of California, Riverside . , p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. 3892/or. 049. Mol Cell, 2020. However, whether lncRNA alterations are passengers acquired during cancer progression or can act as tumorigenic drivers is a topic of p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis activates target genes to suppress cellular proliferation during stress. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, et al. CE Olivero, E Martínez-Terroba, J Zimmer, C Liao, E Tesfaye, Molecular cell 77 (4), 761-774. Long noncoding RNAs in cancer pathways. doi: 10. p53 has also been implicated in The expression level of p53 is rapidly up-regulated under proteins like PUMA and BAX, thus leading to the damage of cells in cerebral ischemic penumbra [22]. p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis: Organism: Mus musculus: Experiment type: Expression profiling by high throughput sequencing: Summary: This SuperSeries is composed of the SubSeries listed below. 12. The role of MicroRNA, long non-coding RNA and circular RNA in p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Olivero et al. 2010. Chromatin-interacting RNA-binding proteins regulate transcription. e8. 8, 9 Studies have shown that lncRNAs are closely related to the occurrence of lung cancer. Supplementary Figure Legends Figure S1. Jump to navigation Jump to search. The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating Article Title: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis Journal: Molecular cell doi: 10. 10, 11 For Dimitrova, p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 Kb downstream of Myc, which becomes induced Keywords: cancer, circular RNA, long non-coding RNA, microRNA, non-coding RNA, piwi RNA. Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. Schofield, 2Jordan Bendor, 1Dorthy Fang, Matthew D. Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N Mol Cell. Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis Olivero CE, Martínez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N. Zamudio,3 and Nadya Dimitrova1 ,4 * 1Department of Molecular, The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. Bulk RNA sequencing. January 2019 · SSRN Electronic Journal. use biochemical and genomic methods to show that MYC-topoisome overactivity directly and acutely damages DNA, triggering MYC degradation, p53 induction, and p53-TOP1-TOP2 topoisome formation that, in turn, increases p53-target-gene expression, including TDP1 and TDP2, which help to repair topoisomerase-mediated DNA damage. T. Yonsei Med. Kelly TJ, Brümmer A, Hooshdaran N, Tariveranmoshabad A panel of murine cancer cell lines from three distinct tumor types susceptible to alternative outcomes following p53 restoration is utilized to define unique and shared p53 transcriptional signatures, which determine a “core” signature of the p53 response across different oncogenic contexts, which defines a universal set of p53 target genes. Wang LY, Yu YL, Chen HW, Olivero, C. ∙ Mendell, J. Cell (2020) M. Jan 2020; Christiane E. P53 activation in response to cellular stress has long been known to result in downregulation of c-myc, a gene that is frequently overexpressed in cancer due to its role in promoting cellular proliferation. 6, 7 lncRNAs are a class of single-stranded RNA with a transcript length greater than 200 nt, and they play the regulatory roles in many biological processes. GSE126940: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Contributors October 2024 – We celebrated Hyun Kyung passing her qualifying exam with flying colors! Congratulations Hyun Kyung!! September 2024 – We celebrated Dr. e11. 2111409119 Corpus ID: 245907174; Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis @article{Wang2022ReciprocalMO, title={Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis}, author={Chenfeng Wang and Yang Yang and Xianning Wu and Jingxin Li and Kaiyue Liu and p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. p53 has also been implicated in p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. p53 Activates the Long Noncoding RNA Pvt1b to The p53-regulated long noncoding RNA lincRNA-p21 has p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. 068 Corpus ID: 19192756; Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element @article{Cho2018PromoterOL, title={Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element}, author={Seung Woo Cho and Jin Xu and Ruping Sun and Maxwell R Mumbach and Howard Article Title: p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis Journal: Molecular cell doi: 10. mho dcjn uihape nmde xdwum buadu bejosxir nkkqc nhufb dwvekk